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Glucosamine with MSM

Rejuvenation Therapeutics


  • Help maintain collagen synthesis and reduce cartilage breakdown.*

Suitable for Vegans. Gluten Free. No artificial fillers, No Rice.

90 Vegan Capsules (1-Month Supply).


Suggested Use: Take 3 capsule daily, or as directed by your qualified healthcare professional.

Warning: Consult a healthcare professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children.

Store in a cool, dry place.

What is Glucosamine?

Glucosamine, 2-amino-2-deoxy-d-glucose, is an amino monosaccharide that is an essential component of mucopolysaccharides and chitin. Glycosaminoglycans (mucopolysaccharides) are large complexes of negatively-charged carbohydrate chains that are incorporated into mucous secretions, connective tissue, skin, tendons, ligaments and cartilage.[1] It is a structural component of Keratin Sulfate (a disaccharide of which Glucosamine sulfate is one of the monosaccharides) and Hyaluronic acid, which is a repeated chain of glucuronic acid and N-acetylglucosamine.[2] Glucosamine and its acetylated derivative, N-acetylglucosamine, are readily synthesized in the body from glucose.[1]

What is MSM?

Methyl sulfonyl methane or MSM is a naturally occurring organosulfur compound derived from lignin. MSM is also known as various others name like dimethyl sulfone, sulphonyl bismethane, organic sulfur or crystalline dimethyl sulfoxide.[3] It is used extensively in joint health supplements, to improve immune function and to reduce inflammation. Being an organosulfur MSM produces free Sulphur in body. This free Sulphur produced by MSM helps in methionine formation which helps in making connective tissues and also participates in other biological functions.

What are the Benefits of Glucosamine with MSM?

  • Glucosamine supports healthy joints. Glucosamine supplements appears to be a highly popular alternative medicine for knee osteoarthritis. (47% of persons confirming usage of alternative medicine with 59% of these users using Glucosamine.)[4]
  • Glucosamine helps in collagen synthesis. Supplements containing glucosamine (1.5g or 3 g) when consumed daily helped to reduce cartilage breakdown and maintain collagen synthesis in athletes involved in various sports, including soccer[5][6] A report states that, 106 athletes with an acute knee injury took either glucosamine (1500 mg daily) or a placebo for 28 days, those in the glucosamine group showed significant improvements in knee flexion and extension compared with the placebo group. Glucosamine sulphate may be most effective in modifying joint structure where joints are less severely affected with osteoarthritis when significant amounts of cartilage are still present[7]
  • MSM lowers muscle pain, spasms and damage. A study published in Journal of sports medicine and physical fitness found that only 10 days of MSM supplementation helped to decrease muscle damage.[8, 9]
  • Combined supplementation of Glucosamine and MSM reduces joint swelling. A study was conducted using both of glucosamine (1500 mg) and MSM (1500 mg) group as well there combination and a placebo noted that the combination therapy was given satisfactory results to the person with knee osteoarthritis in terms of joint swelling.[10]

Why Take Glucosamine with MSM Supplements?

The Glucosame+MSM supplements can be taken by any person suffering from osteoarthritis, knee pain occurring from injury or cartilage breakdown. Daily intake of 1500 mg of glucosamine is the most widely recommended dose, however up to 3g daily may be taken for additional benefits. Our Glucosamine+MSM supplements additionally provides potassium and chloride salts which help to improve cardiovascular health, bone health, regulates blood pressure and increases muscle strength. Each dose of Glucosamine+MSM supplements contains 1500 mg of Glucosamine sulphate potassium chloride salt and 600 mg of methyl sulphonyl methane.


  1. Anderson, J. W., Nicolosi, R. J., & Borzelleca, J. F. (2005). Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food and Chemical Toxicology, 43(2), 187-201.
  2. Dahmer, S., & Schiller, R. M. (2008). Glucosamine. American family physician, 78(4).
  3. Bertken, R. (1983). “Crystalline DMSO”: DMSO2. Arthritis & Rheumatology, 26(5), 693-694.
  4. Lapane, K. L., Sands, M. R., Yang, S., McAlindon, T. E., & Eaton, C. B. (2012). Use of complementary and alternative medicine among patients with radiographic-confirmed knee osteoarthritis. Osteoarthritis and cartilage, 20(1), 22-28.
  5. Yoshimura, M., Sakamoto, K., Yamamoto, T., Ishida, K., Yamaguchi, H., & Nagaoka, I. (2009). Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. International journal of molecular medicine, 24(4), 487-494.
  6. Momomura, R., Naito, K., Igarashi, M., Watari, T., Terakado, A., Oike, S., & Kaneko, K. (2013). Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers. Molecular medicine reports, 7(3), 742-746.
  7. Bruyère, O., Honore, A., Ethgen, O., Rovati, L. C., Giacovelli, G., Henrotin, Y. E., & Reginster, J. Y. (2003). Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis and Cartilage, 11(1), 1-5.
  8. Usha, P. R., & Naidu, M. U. R. (2004). Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical drug investigation, 24(6), 353-363.
  9. Barmaki, S., Bohlooli, S., Khoshkhahesh, F., & Nakhostin-Roohi, B. (2012). Effect of methylsulfonylmethane supplementation on exercise—Induced muscle damage and total antioxidant capacity. Journal of Sports Medicine and Physical Fitness, 52(2), 170.
  10. Nakasone, Y., Watabe, K., Watanabe, K., Tomonaga, A., Nagaoka, I., Yamamoto, T., & Yamaguchi, H. (2011). Effect of a glucosamine-based combination supplement containing chondroitin sulfate and antioxidant micronutrients in subjects with symptomatic knee osteoarthritis: A pilot study. Experimental and therapeutic medicine, 2(5), 893-899.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.