Rejuvenate with NiaSun® Supplement
NiaSun® supplement provides a potent boost of nicotinamide riboside (NR), a natural compound found in every cell of your body, and that of every animal and plant on Earth.
Recent scientific advances from major universities around the world have uncovered some of the secrets of the aging process. Now, Rejuvenation Therapeutics® has put the latest-discovered anti-aging compounds into vegan capsules for you.
NiaSun® is a new breakthrough compound targeting aging and mitochondrial health through Nicotinamide Riboside (NR) supplement. Research has indicated that natural NR supplements may provide the necessary boost needed to combat age-related NAD+ decline.
How Does NiaSun® Help?
NiaSun® is a potent source of NR, which elevates levels of NAD+ in the blood. Restored NAD+ could give cells the potential to work more effectively by restoring mitochondrial function.
What is NAD+?
NAD+ is a naturally-occurring molecule found in healthy mitochondria, used for generating energy, and essential for normal cellular function. Declining cellular and mitochondrial NAD+ has been linked to aging and age associate diseases (Read more about this in the paper titled ‘NAD+ in aging, metabolism, and neurodegeneration‘)
What is NR?
NR is a normal biological product (metabolite) of Vitamin B3. It is essential for the generation of cellular energy via the central energy molecule NAD+. As a precursor to NAD+, NR works in all major areas of our cells, including the powerhouses: the mitochondria. NiaSun is first taken up by the body and converted into NMN (Nicotinamide Mononucleotide), and then into NAD+ (Nicotinamide Adenine Dinucleotide). NAD+ is not easily absorbed by the body; when swallowed, it is broken down in the GI tract. However, NiaSun is easily absorbed and is stable when swallowed as capsules.
In model (mice) studies, NR has been shown to turn back the aging process. According to Harvard Medical School researchers, referring to NMN: “Our data show that 1 week of treatment with a compound that boosts NAD+ levels is sufficient to restore the mitochondrial homeostasis and key biochemical markers of muscle health in a 22-month-old mouse to levels similar to a 6-month-old mouse.”1 As people age, levels of NAD+ decline dramatically. This affects many things, including the ability of cells to repair and sustain themselves. NR has been shown to restore essential NAD+ levels in cells2.
NR serves as a powerful NAD+ precursor and a Sirtuin activator with the potential to protect mitochondrial health. Model (animal) studies have shown that this could be an effective means to slow down the aging process by restoring mitochondrial function3.
In model studies, NR has been shown to lower the total cholesterol and protect cellular integrity in the livers of obese and diabetic mice. In mammalian cells, NR supplementation increases NAD+ levels and activates SIRT1 and SIRT 3 to enhance metabolism and protect against high-fat diet-induced health conditions4.
By stimulating NAD+ synthesis, NR may possess neuroprotective effects in the brain that benefit cognitive function and synaptic plasticity. There are ongoing clinical studies to measure the effect of NR on brain NAD+5
- Gomes, Ana P., et al. “Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.” Cell 155.7 (2013): 1624-1638.
- Imai, Shin-ichiro, and Leonard Guarente. “NAD+ and sirtuins in aging and disease.” Trends in cell biology 24.8 (2014): 464-471.
- Cerutti R, Pirinen E, Lamperti C, et al. “NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease”. Cell Metabolism. 2014;19(6):1042-1049. doi:10.1016/j.cmet.2014.04.001.
- Yoshino J(1), Mills KF, Yoon MJ, Imai S. “Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice”. Cell Metab. 2011 Oct 5;14(4):528-36. doi: 10.1016/j.cmet.2011.08.014.
- Bogan, Katrina L., and Charles Brenner. “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.” Annu. Rev. Nutr. 28 (2008): 115-130.
What is Niasun?
Each vegan-friendly vegetable capsule contains 100 mg of Nicotinamide Riboside, which can easily be absorbed by the body upon oral consumption. Our capsules are pure inside and out: vegetarian, free of lactose, gluten, preservatives, additives, and with minimal excipients. Our BPA-free bottle provides protection from heat, light, and air.
How much NiaSun should I order?
We recommend that customers start with three bottles, but we do offer additional options to suit a variety of needs. Our 6-bottle package is the best value, or you can try a single bottle as well.
How do I take NiaSun?
It’s a very simple regime of one capsule per day in the morning. You can take it on an empty stomach with a glass of water.
Is NiaSun right for me?
NiaSun can be taken by anybody, whether you want an effective defense against aging or you’re just looking for something to boost energy, performance, and overall wellbeing. A recent clinical study demonstrated that NR supplementation is safe and can effectively increase the concentration of NAD+. As a highly effective NAD+ precursor, NR has been shown to restore declining NAD+ levels to support cellular function. Working from a cellular level, NiaSun may be the key to preserving and restoring your health.
- Cantó, Carles, et al. “The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.”Cell metabolism 15.6 (2012): 838-847.
- Gong, Bing, et al. “Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models.”Neurobiology of aging 34.6 (2013): 1581-1588.
- “Results from First Human Clinical Study Demonstrate ChromaDex’s NIAGEN(R) Nicotinamide Riboside Effectively Increases the Co-enzyme NAD+ and Is Safe.” GlobeNewswire News Room. GlobeNewswire, 12 Aug. 2015. Web. 20 Oct. 2015.