Suggested Use: Take 2-4 capsule daily, or as directed by your qualified healthcare professional.
Warning: Consult a healthcare professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children.
Store in a cool, dry place.
What is D-Mannose?
D-Mannose is the C2 epimer of the sugar D-Glucose. D-Mannose can be obtained from plant sources such as Chinese jujube, hemicellulose hydrolysate of orange peel, litchi pericarp, apple flesh, cranberries, mangoes, used coffee grounds, etc. It can also be found in baker’s yeast, human serum and egg albumin. D-Mannose is an intermediate product required by the human body in protein and glycoprotein synthesis.
D-Mannose can benefit our immune system and have beneficial effects against urinary tract infections (UTIs), diabetes, metabolic syndrome, and other conditions.[1-3]
What are the Benefits of D-Mannose?
D-Mannose supports urinary tract health, by binding to floating E. coli bacteria in the urine. This can help with eliminating E. coli related UTIs when taken prophylactically.[4-6]
D-Mannose was shown to be beneficial in managing UTI in women with acute cystitis. D-Mannose when taken prophylactically after UTIs can reduce the recurrence of UTIs, which was similar to the prophylactic effects of a standard antibiotic. D-Mannose showed lesser occurrence of UTIs when used by Multiple Sclerosis patients as a preventative agent, both in patients with or without catheters. D-Mannose supplements when taken in combination with N-Acetyl Cysteine and Morinda citrifolia extract has also shown preventative properties in UTI.
Research from decades back indicated the rapid metabolic effects of D-Mannose. D-Mannose has insulin secretary effects on the pancreas and enhances insulin sensitivity.[1, 9] D-Mannose supplementation is beneficial in autoimmune responses in diabetes and inflamed lungs in asthma, and additionally mannose binding proteins are involved in immune response pathways.[1, 10-12]
Why Take D-Mannose Supplements?
D-Mannose can help in managing UTI caused by E. coli strains and prevent recurrence of a UTI when taken regularly after a UTI treated with an antibiotic. It is rapidly metabolized in the body and less likely to be stored as fat, hence it can be used as a sugar substitute. Most common dosages in clinical studies were ranging from 2000 mg to 3000 mg daily.[1-5, 7]
What are the Most Common Side Effects of Taking D-Mannose?
Diarrhea is the most common side effect associated with D- Mannose use.[2, 14-18] D-mannose can cause loose stools and bloating.[16-18]
What are the Precautions and Warnings with D-Mannose Use?
Higher doses of D-Mannose can cause kidney problems.[15, 16] D-Mannose may cause blood sugar problems, so patients with diabetes should avoid using D-Mannose or use it with caution. Avoid using of D-Mannose during pregnancy and breastfeeding since no current evidence is available for these conditions.[15, 16]
- Xing Hu, Yaning Shi, Peng Zhang, Ming Miao, Tao Zhang, and Bo Jiang. D-Mannose: Properties, Production, and Applications: An Overview. Comprehensive Reviews in Food Science and Food Safety. 2016 May:15:773-785. https://doi.org/10.1111/1541-4337.12211
- Kranjčec B, Papeš D, Altarac S. D-Mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology. 2014 Feb;32(1):79-84. doi: 10.1007/s00345-013-1091-6. Epub 2013 Apr 30.
- Domenici L, Monti M, Bracchi C, Giorgini M, Colagiovanni V, Muzii L, Benedetti Panici P. D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci. 2016 Jul;20(13):2920-5.
- Lenard L and Wright JV. D-Mannose: Natural Treatment for Urinary Tract Infections. http://johnappleton.co.nz/media/wysiwyg/articles/D_MANNOSE.pdf. Accessed Mar 2018
- Schaeffer AJ, Chmiel JS, Duncan JL, Falkowski WS. Mannose-sensitive adherence of Escherichia coli to epithelial cells from women with recurrent urinary tract infections. J Urol. 1984 May;131(5):906-10.
- Eris D, Preston RC, Scharenberg M, Hulliger F, Abgottspon D, Pang L, Jiang X, Schwardt O, Ernst B. The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target? Chembiochem. 2016 Jun 2;17(11):1012-20. doi: 10.1002/cbic.201600066. Epub 2016 Apr 21.
- Phé V, Pakzad M, Haslam C, Gonzales G, Curtis C, Porter B, Chataway J, Panicker JN. Open label feasibility study evaluating D-mannose combined with home-based monitoring of suspected urinary tract infections in patients with multiple sclerosis. Neurourol Urodyn. 2017 Sep;36(7):1770-1775. doi: 10.1002/nau.23173. Epub 2016 Nov 4.
- Palleschi G, Carbone A, Zanello PP, Mele R, Leto A, Fuschi A, Al Salhi Y, Velotti G, Al Rawashdah S, Coppola G, Maurizi A, Maruccia S, Pastore AL. Prospective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation. Arch Ital Urol Androl. 2017 Mar 31;89(1):45-50. doi: 10.4081/aiua.2017.1.45.
- Ganda OP, Soeldner JS, Gleason RE, Cleator IG, Reynolds C. Metabolic effects of glucose, mannose, galactose, and fructose in man. J Clin Endocrinol Metab. 1979 Oct;49(4):616-22.
- Shi YB1, Yin D2. A good sugar, d-mannose, suppresses autoimmune diabetes. Cell Biosci. 2017 Sep 25;7:48. doi: 10.1186/s13578-017-0175-1. eCollection 2017.
- Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, Chen Q, Sun L, Chen ZJ, Chen W. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23(9):1036-1045. doi: 10.1038/nm.4375. Epub 2017 Jul 24.
- Sager CP, Eriş D, Smieško M, Hevey R, Ernst B. What contributes to an effective mannose recognition domain? Beilstein J Org Chem. 2017 Dec 4;13:2584-2595. doi: 10.3762/bjoc.13.255. eCollection 2017.
- Pitkänen OM1, Vanhanen H, Pitkänen E. Scand J Clin Lab Invest. Metabolic syndrome is associated with changes in D-mannose metabolism. 1999 Dec;59(8):607-12.
- Altarac S, Papeš D. Use of D-mannose in prophylaxis of recurrent urinary tract infections (UTIs) in women. BJU Int. 2014 Jan;113(1):9-10. doi: 10.1111/bju.12492.
- Salinas-Casado J, Méndez-Rubio S, Esteban-Fuertes M, Gómez-Rodríguez A, Vírseda-Chamorro M, Luján-Galán M, Rituman G. [Efficacy and safety of D-mannose (2 g), 24h prolonged release, associated with Proanthocyanidin (PAC), versus isolate PAC, in the management of a series of women with recurrent urinary infections.] [Article in Spanish] Arch Esp Urol. 2018 Mar;71(2):169-177.
- https://www.webmd.com/vitamins/ai/ingredientmono-1114/d-mannose Accessed Apr 2018
- https://www.rxlist.com/d-mannose/supplements.htm Accessed Apr 2018
- Horvath A1, Dziechciarz P, Szajewska H. Glucomannan for abdominal pain-related functional gastrointestinal disorders in children: a randomized trial. World J Gastroenterol. 2013 May 28;19(20):3062-8. doi: 10.3748/wjg.v19.i20.3062.
|* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.