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Glucosamine

Rejuvenation Therapeutics

RTX-DS2700-090

  • Help maintain collagen synthesis and reduce cartilage breakdown.*

Suitable for Vegans. Gluten Free. No artificial fillers, No Rice.

90 Vegan Capsules (-1Month Supply).

   FREE SHIPPING ON ORDERS OVER $25!

Suggested Use: Take 3 capsule daily, or as directed by your qualified healthcare professional.

Warning: Consult a healthcare professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children.

Store in a cool, dry place.


What is Glucosamine?

Glucosamine, 2-amino-2-deoxy-d-glucose, is an amino monosaccharide that is an essential component of mucopolysaccharides and chitin. Glycosaminoglycans (mucopolysaccharides) are large complexes of negatively-charged carbohydrate chains that are incorporated into mucous secretions, connective tissue, skin, tendons, ligaments and cartilage.[1] It is a structural component of Keratin Sulfate (a disaccharide of which Glucosamine sulfate is one of the monosaccharides) and Hyaluronic acid, which is a repeated chain of glucuronic acid and N-acetylglucosamine.[2] Glucosamine and its acetylated derivative, N-acetylglucosamine, are readily synthesized in the body from glucose.[1]


What are the Benefits of Glucosamine?

Glucosamine appears to be a highly popular alternative medicine for knee osteoarthritis (47% of persons confirming usage of alternative medicine with 59% of these users using Glucosamine and 54% using Chondroitin)[3] and highly used in general, with one survey noting that 5% of the US population used glucosamine supplementation with up to 7 and 9% of elderly women and men, respectively.[4] Glucosamine has several health benefits. Glucosamine supplements (1.5g or 3 g daily) helped to reduce cartilage breakdown and maintain collagen synthesis in athletes involved in various sports, including soccer [5] and bicycle racers.[6] A report states that, 106 athletes with an acute knee injury took either glucosamine (1500 mg daily) or a placebo for 28 days, those in the glucosamine group showed significant improvements in knee flexion and extension compared with the placebo group. Glucosamine sulphate may be most effective in modifying joint structure where joints are less severely affected with osteoarthritis when significant amounts of cartilage are still present.[7]

Researchers from the University of Washington and the Fred Hutchinson Cancer Research Centre, both in Seattle, found that, out of 77,719 people aged 50 to 76, those who were taking glucosamine on at least four days a week, for at least three years, were 17% less likely to die from any cause than non-users over the following five years.[8]


Why Take Glucosamine Supplements?

Supplements serve as a convenient option for anyone looking to improve the joint health and get rid of knee pain due to osteoarthritis. Daily intake of 1500 mg is the most widely recommended dose, however up to 3g daily may be taken for additional benefits. Although, to supplement glucosamine, take 300 – 500 mg, three times a day, for a total daily dose of 900 – 1,500 mg. The benefits of glucosamine are dose-dependent, and studies use up to 2,000 – 3,000 mg a day, taken in several doses.

Glucosamine sulphate salts are the best way to supplement glucosamine, with glucosamine sulphate as a close second. Glucosamine hydrochloride is ineffective.

N-Acetyl glucosamine is not glucosamine and should be considered a different supplement. Glucosamine should be supplemented alongside food.


What are the Side Effects of Glucosamine Ingestion?

  • Although glucosamine is not allergenic, other bioactives from its source (shellfish) may be found in some dietary supplements and thus persons with shellfish allergies should take caution in using glucosamine supplementation.
  • Although there does not appear to be a large adverse interaction between glucosamine and diabetes (some schools of thought believe that glucosamine induces insulin resistance, which doesn't appear to be that reliable in humans after oral ingestion) it still seems to be prudent to ask a medical doctor about using glucosamine if one is pre-diabetic or diabetic.

References

  1. Anderson, J. W., Nicolosi, R. J., & Borzelleca, J. F. (2005). Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food and Chemical Toxicology, 43(2), 187-201.
  2. Dahmer, S., & Schiller, R. M. (2008). Glucosamine. American family physician, 78(4).
  3. Lapane, K. L., Sands, M. R., Yang, S., McAlindon, T. E., & Eaton, C. B. (2012). Use of complementary and alternative medicine among patients with radiographic-confirmed knee osteoarthritis. Osteoarthritis and cartilage, 20(1), 22-28.
  4. Center, S. E. (2006). Patterns of medication use in the United States, 2006: a report from the Slone Survey. Boston: Boston University, 3.
  5. Yoshimura, M., Sakamoto, K., Yamamoto, T., Ishida, K., Yamaguchi, H., & Nagaoka, I. (2009). Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. International journal of molecular medicine, 24(4), 487-494.
  6. Momomura, R., Naito, K., Igarashi, M., Watari, T., Terakado, A., Oike, S., & Kaneko, K. (2013). Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers. Molecular medicine reports, 7(3), 742-746.
  7. Bruyère, O., Honore, A., Ethgen, O., Rovati, L. C., Giacovelli, G., Henrotin, Y. E., & Reginster, J. Y. (2003). Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis and Cartilage, 11(1), 1-5.
  8. Pocobelli, G., Kristal, A. R., Patterson, R. E., Potter, J. D., Lampe, J. W., Kolar, A., & White, E. (2010). Total mortality risk in relation to use of less-common dietary supplements. The American journal of clinical nutrition, ajcn-28639.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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