Suggested Use: Take 1 capsule daily, or as directed by your qualified healthcare professional.

Warning: Consult a healthcare professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children.

Store in a cool, dry place.

What is Fisetin?

Fisetin is a bioactive flavonol molecule found in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber at concentrations in the range of 2–160μg/g.^[1] Fisetin was found to be one of the potent antioxidant flavonoids among the evaluated flavonoids.^[2] It exerts multiple beneficial pharmacological activities such as anti-inflammatory, anti-cancer, hypolipidemic and in rheumatoid arthritis.^[3] Fisetin has shown anti-cancer activity in studies on cells and model animals conducted in laboratories.^[4]

What are the Benefits of Fisetin?

• Fisetin has been studied by researchers at the Salk Institute for Biological Studies as a memory enhancer. Laboratory and animal studies have found that it protects and promotes the growth of brain cells and enhances memory in mice.^[5]
• It has been shown to maintain levels of glutathione (the primary antioxidant internal to most cells in the body) in the presence of oxidative stress.
• Fisetin has been shown to affect multiple pathways involved in the maintenance of neuronal function during aging. It acts as an antioxidant, increases GSH, maintains mitochondrial function in the presence of oxidative stress, has anti-inflammatory activity against microglial cells, and inhibits the activity of 5-lipoxygenase, signifying that fisetin causes reduction in the age-related decline in brain function^[2].
• In addition, it has anti-inflammatory activity and inhibits the activity of lipoxygenases, thereby reducing the production of pro-inflammatory eicosanoids and their by-products. This wide range of actions suggests that fisetin has the ability to reduce the impact of age-related neurological diseases on brain function.^[6]
• It's proven ability toinhibit oxidation of harmful LDL cholesterol also indicates fisetin’s potential in preventing cardiovascular disease.^[7]
• Emerging data fromin vitro andin vivo studies indicate that fisetin possesses antiproliferative properties against several cancers.^{[1, 8, 9]}
• Fisetin-rich RVS extracts (Rhus verniciflua Stokes) have potential anti-platelet and anti-obesity activities and could be used as a functional food ingredient to improve blood circulation.^[10]
• Fisetinalso inhibits UVB-induced collagen degradation – a key factor in skin aging.^[11]

Why Take Fisetin Supplements?

Although present in strawberries, fisetin is a relatively rare nutrient found only in minute quantities in the plant kingdom. Fisetin supplements serve as a convenient option to increase a daily intake of this flavonoid, which has memory enhancing, anti-inflammatory, anti-cancer, anti-platelet and anti-obesity properties.^{[5, 6, 8-10]} It also has potential in preventing cardiovascular diseases.^[7]

References

1. Naghma Khan, Deeba N. Syed, Nihal Ahmad, Hasan Mukhtar. Fisetin: A Dietary Antioxidant for Health Promotion. Antioxid Redox Signal. 2013 Jul 10; 19(2): 151–162.
2. Maher P (2009) Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr 4: 297–307.
3. Leotoing L, Wauquier F, Guicheux J, Miot-Noirault E, Wittrant Y, et al. (2013) The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. PLoS ONE 8: e68388.
4. Syed, DN; et al. (Sep 2013). Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med Chem. 13 (7): 995–1001.
5. Pamela Maher. Methods of using flavonoids to enhance memory US 7897637 B2. The Salk Institute For Biological Studies
6. Maher P(2015) Fisetin acts on multiple pathways to reduce the impact of age and disease on CNS function. Front Biosci (Schol Ed) 7, 58-82
7. Masternak MM, Bartke A. PPARs in calorie restricted and genetically long-lived mice. PPAR Res. 2007;2007:28436.
8. Syed DN, Suh Y, Afaq F, Mukhtar H. Dietary agents for chemoprevention of prostate cancer. Cancer Lett. 2008 Jul 8; 265(2):167-76.  
9. Jankun J, Selman SH, Aniola J, Skrzypczak-Jankun E. Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment. Oncol Rep. 2006 Aug; 16(2):341-6.
10. Im WK, Park HJ, Lee KS, Lee JH, Kim YD, Kim KH, Park SJ, Hong S, Jeon SH. Fisetin-Rich Extracts of Rhus verniciflua Stokes Improve Blood Flow Rates in Mice Fed Both Normal and High-Fat Diets. J Med Food. 2016 Feb;19(2):120-6
11. Chiang HM, Chan SY, Chu Y, Wen KC. Fisetin Ameliorated Photodamage by Suppressing the Mitogen-Activated Protein Kinase/Matrix Metalloproteinase Pathway and Nuclear Factor-κB Pathways. J Agric Food Chem. 2015 May 13;63(18):4551-60
12. Integrative Medicine E-Book. David Rakel Elsevier Health Sciences, 21-Mar-2017 - Medical - 1072 pages

Suggested Use: Take 1 capsule daily, or as directed by your qualified healthcare professional.

Warning: Consult a healthcare professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children. Do not take vitamin K supplements if you are taking anticoagulant drugs.

Store in a cool, dry place.

What is Vitamin K2 MK-7?

Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body requires for complete synthesis of certain proteins that are prerequisites for blood coagulation. The body also needs these proteins for controlling binding of calcium in bones and other tissues. Vitamin K includes two natural vitamers: vitamin K1 and vitamin K2. Vitamin K1 is made in plants and algae; green leafy vegetables are a particularly rich source. On the other hand, bacteria generate vitamin K2, which can also be found in meat, dairy, eggs, and fermented foods, such as cheese, yogurt, and natto—a Japanese dish of fermented soybeans

Vitamin K2 or menaquinone, is essential for calcium use, helping build strong bones and inhibiting arterial calcification.^[1] It has nine related compounds, generally subdivided into the short-chain menaquinones (with MK-4 as the most important member) and the long-chain menaquinones, of which MK-7, MK-8 and MK-9 are nutritionally the most recognized.

What are the benefits of Vitamin K2 MK-7?

Studies have shown that supplementation with K2MK7 can reduce vascular calcification in patients with CAD, and decreases arterial stiffness post-menopausal women.^{[2, 3]} An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls.

In another study on K2MK7 for rheumatoid arthritis, in the MK-7 treated group, a marked decrease in RA clinical and biochemical markers was observed.^[4]

Why take Vitamin K2 MK-7 supplements?

Vitamin K, particularly as vitamin K2, is present in very little amounts even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 could therefore lower calcium-associated health risks. Vitamin K2 is most active as the MK-7 form, which is present in natto. Research has shown that increased consumption of MK-7 leads to more activated osteocalcin, which is linked to increased bone-matrix formation and bone mineral density and, therefore, a lower risk of hip fracture.^{[5, 6]} Those results were confirmed in a 3-year study with 944 women aged 20 to 79 years, which showed that intake of MK-7-rich natto was associated with the preservation of bone mineral density.^[7] One recent, double-blind, randomized clinical trial investigated the effects of supplemental MK-7, MenaQ7 (NattoPharma ASA, Hovik, Norway), within a 3-year period for a group of 244 postmenopausal women. The researchers found that a daily dose of 180 mcg was enough to improve bone mineral density, bone strength, and cardiovascular health.^[8]

References

1. Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. 2007 Apr 15; 109(8):3279-83.
2. Vossen, Liv M., et al. “Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: rationale and study protocol (VitaK-CAC Trial).” Nutrients11 (2015): 8905-8915.
3. Knapen, M. H., et al. “Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.” Thromb Haemost5 (2015): 1135-44.
4. Abdel-Rahman, Mahran S., Eman AM Alkady, and Sameh Ahmed. “Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study.” European journal of pharmacology 761 (2015): 273-278.
5. Kaneki M, Hodges SJ, Hosoi T, et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. 2001;17(4):315–321.
6. Schurgers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer C. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. 2007;109(7):2823–2831.
7. Ikeda Y, Iki M, Morita A, et al. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study.J Nutr. 2006;136(5):1323–1328.
8. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. 2007;18(7):963–972.

Suggested Use: Take 2 capsules once daily, or as directed by your qualified healthcare professional.

Warning: Consult a healthcare professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children.

Store in a cool, dry place.

Certified Organic by Quality Assurance International.

What is Elderberry?

Elderberry comes under the genus Sambucus and family Adoxaceae. These are flowering plants and bear cluster of small white and cream colour blooms in late spring, followed by cluster of small black, blue black or red colour berries. The genus Sambucus are mainly found in temperate to subtropical regions. These berries are used as folk medicines by North America, Europe, and Western Africa for centuries. The most commonly found elderberry species is Sambucus nigra. Elderberry based medication recipes were found in ancient Egyptians literatures. Greeks had described these berries as ‘medicine chest’ because of wide array of health concern it seemed to cure. Apart from its medicinal value these fruits are also used for making wine and as a food flavouring. Health benefit of elderberry include naturally improving cold, flu, sinus, inflammation, fatigue, allergies and nerve pain. Elderberries contain amino acids, carotenoids, flavonoids, sugar, rutin, vitamin A and B and large amount of Vitamin C. The major flavonoids found in elderberries are quercetin and anthocyanin which are powerful antioxidants and protects cell from damages.^[1]

What are the benefits of Elderberry?

• Elderberries are excellent immune system booster The Elderberry extract has been shown to be a safe, efficient and cost effective treatment for flu and cold. A study published in the Nutrients journal reveals that the elderberry supplements can reduce the duration and symptoms of cold and flu in air travelers.^[2]
• The flavonoids presents in the elderberry extract bind to the H1N1 human influenza virus and H5N1avian influenza virus. Elderberry extract are effective in controlling influenza symptoms.^[3]
• With Elderberry’s anti-inflammatory and anti-oxidant properties it also helps in clearing up sinus infection.^[4]
• Extracts of Elderflower stimulates glucose metabolism and the secretion of insulin and thus lowers the blood sugar level.^[5]
• Elderberry has natural diuretic effects which helps to promote the urination and bowel system.^[6]

Why take Elderberry?

Elderberry supplements serve as a convenient option for anyone looking to improve the immunity level, take precaution against cold, influenza, allergy symptoms and get rid of fatigue. Our elderberry supplement contains 125 mg of standardized elderberry organic extract powder of Sambucus nigra.

What are the Side Effects of Elderberry Ingestion?

• Raw and unripe fruit of Elderberry might cause nausea, vomiting or severe diarrhea.
• The juice or extract of elderberry shall not be consumed by a person if he or she is suffering from autoimmune diseases like multiple sclerosis, lupus or rheumatoid arthritis. Elderberry juice or extract might trigger the immune system to be more active and this could increase the symptoms of the auto immune diseases.

References

1. Youdim, K. A., Martin, A., & Joseph, J. A. (2000). Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress1. Free Radical Biology and Medicine, 29(1), 51-60.
2. Tiralongo, E., Wee, S. S., & Lea, R. A. (2016). Elderberry supplementation reduces cold duration and symptoms in air-travellers: A randomized, double-blind placebo-controlled clinical trial. Nutrients, 8(4), 182.
3. Kong, F. K. (2009). Pilot clinical study on a proprietary elderberry extract: efficacy in addressing influenza symptoms. Online Journal of Pharmacology and Pharmacokinetics, 5, 32-43.
4. Melzer, J., Saller, R., Schapowal, A., & Brignoli, R. (2006). Systematic Review of Clinical Data with BNO-101 (Sinupret?) in the Treatment of Sinusitis. Complementary Medicine Research, 13(2), 78-87.
5. Gray, A. M., Abdel-Wahab, Y. H., & Flatt, P. R. (2000). The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. The Journal of nutrition, 130(1), 15-20.
6. Wright, C. I., Van-Buren, L., Kroner, C. I., & Koning, M. M. G. (2007). Herbal medicines as diuretics: a review of the scientific evidence. Journal of ethnopharmacology, 114(1), 1-31.